《医学院大讲堂 第393期》李斌 教授：椎间盘再生：生物材料与多模力学调节

以下内容根据公开信息整理，并经大模型处理生成，可能存在疏漏或误差，请以实际信息为准。

• 题目: 椎间盘再生：生物材料与多模力学调节
• 主讲人：李斌 教授 @ 苏州大学
• 时间：2026年6月13日 10:00-11:00
• 地点：会议中心405

主讲人简介

李斌，教授，国家杰青，江苏特聘医学专家，苏州大学苏州医学院执行院长，骨科研究所副所长，苏大附一院医学3D打印中心主任。1996和2001年分别获得清华大学学士和博士学位，先后在新加坡材料工程研究院和美国匹兹堡大学从事研究。入选美国医学与生物工程院、国际生物材料科学与工程学会联合会、国际骨科研究联合学会、国际华人骨研学会及中国生物材料学会会士（Fellow）。现任国际华人骨研学会发展委员会主席，中国生物医学工程学会理事、组织工程与再生医学分会候任主委，中国生物材料学会理事、智能仿生生物材料分会副主委。发表论文220余篇，参编专著14部，发明专利20余项。任Biomed Mater主编，J Orthop Transl副主编。主持国家自然科学基金重点项目、国家重点研发计划项目。

讲座简介

A major cause of neck and low back pains, degenerative disc disease (DDD) has become a prevailing health problem worldwide and significantly contributes to healthcare expenditures. Current conservative or surgical treatments for DDD can hardly reverse the biological function of degenerated intervertebral disc (IVD) and in some cases, may even lead to degenerative changes in adjacent vertebrae. In the last two decades, there has been a surge of interest in fabricating IVD replacements using tissue engineering strategies for DDD therapy. However, major challenge remains toward fabricating annulus fibrosus (AF) replacements that are biologically and functionally comparable to native tissue, largely due to the tremendous complexity of AF tissue at cellular, biochemical, microstructural, and biomechanical aspects. In recent years, we have employed a combination of tissue engineering strategies including layer-by-layer assembly, multimodal mechano-regulation, controlled drug delivery, and 3D printing in order to address the heterogeneity feature of AF tissue toward effective IVD regeneration. Findings from these studies may provide new insights toward developing engineered IVDs whose biological features and mechanical functions approximate those of native tissue.

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