《南科大讲堂 第439期》Jin-Quan Yu 教授：双功能配体合成C-H活化：从好奇心到工业化

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  • 题目: 双功能配体合成C-H活化：从好奇心到工业化
  • 主讲人：Jin-Quan Yu 教授 @ Scripps Research
  • 时间：2026年6月15日 10:00-12:00
  • 地点：Lecture Hall 1142, College of Science

主讲人简介

Professor Jin-Quan Yu is Professor of Chemistry at Scripps Research, where he holds the Bristol Myers Squibb Chair in Chemistry and the Frank and Bertha Hupp Professorship in Chemistry. His research focuses on the rational design and serendipitous discovery of new reactions through C–H activation. He received his B.S. in Chemistry from East China Normal University, his M.S. in Organic Chemistry from the Guangzhou Institute of Chemistry, Chinese Academy of Sciences, and his Ph.D. in Organic Chemistry from the University of Cambridge. His pioneering work in C–H activation has been recognized with the 2016 MacArthur Fellowship (“Genius Grant”), election to the American Academy of Arts and Sciences in 2019, and election to the National Academy of Sciences and as a Fellow of the Royal Society, the United Kingdom’s national academy of sciences, in 2026.

讲座简介

The widespread presence of C–H bonds at various sites of synthetic substrates renders C–H activation the most powerful platform for developing catalytic reactions for synthesis. Among numerous challenges, achieving enantioselective C–H activation via asymmetric metalation stands out as a holy grail in chemistry. Despite century-long efforts, seeking solutions to this problem has met with limited success due to a fundamental challenge: lack of ligands that can accelerate C–H activation reactions. By combining the weak coordination (entropy) from substrates and ligand acceleration (enthalpy), we have realized enantioselective C–H activation using all major approaches in classic asymmetric catalysis including desymmetrization, kinetic resolution, dynamic kinetic resolution, and enantioselection. Most notably, eight generations of bi-functional ligands (MPAA, APAQ, APAO, MPAAm, MPAThio, Pyridine-Pyridone, Amine-Pyridone, Amide-Pyridone) have been developed to enable a wide range of enantioselective and site-selective C–H activation reactions of diverse classes of native substrates for the construction of point, axial and planar chirality. In parallel, we have realized C–H hydroxylation using molecular oxygen or aqueous hydrogen peroxide as the terminal oxidants, paving the way for large-scale industrialization. Applications of our catalysts and reactions at BMS, Vertex, Lilly, Merck and Pfizer will be highlighted.

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